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Promising to talk the reality about America’s previous, Kamala Harris informed the Nationwide Congress of American Indians that the Biden administration wouldn’t shrink back from a historical past, because the first arrival of European explorers, that she stated was “shameful”.

The US vice-president additionally highlighted an “epidemic” of murders of Native American ladies and ladies, which she stated “should finish”.

Harris delivered a digital handle the day after a federal vacation initially named for Christopher Columbus, the Italian explorer who arrived within the Americas in 1492.

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The naming of the vacation for Columbus, a slaveholder and dealer who introduced illness in addition to oppression to the Americas, has confirmed more and more controversial, criticized on the left and defended on the appropriate and amongst some Italian heritage teams.

The White Home this yr issued twin proclamations, greeting each Columbus Day and Indigenous Peoples’ Day.

  • Why is the identify of the day so controversial? In a bitterly divided nation, the instructing of American historical past has turn out to be a political flashpoint, attracting fierce assaults from conservatives all over the place from college boards to universities, the media and past.

  • What else did Harris say about it? “Since 1934, each October, the USA has acknowledged the voyage of the European explorers who first landed on the shores of the Americas. However that isn’t the entire story. That has by no means been the entire story … We should not shrink back from this shameful previous.”

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Drug trial affords new hope for these with metastatic breast most cancers

Breast scan
Secondary breast most cancers happens when the most cancers spreads to different elements of the physique. {Photograph}: Bsip Sa/Alamy

Scientists have launched a trial that would provide hope to folks with incurable breast most cancers. They’re finding out whether or not an current drug, talazoparib, additionally recognized by the model identify Talzenna, could provide a brand new therapy to folks with incurable breast most cancers that has unfold to the mind.

Secondary breast most cancers, also called metastatic breast most cancers, happens when the most cancers has unfold from the breast to different elements of the physique, the place it turns into incurable. Final month it claimed the lifetime of the Ladies Aloud singer Sarah Harding.

Within the new trial, funded by the charity Breast Most cancers Now, researchers will assess whether or not talazoparib might assist folks with terminal breast most cancers. The drug is a PARP inhibitor, which works by stopping most cancers cells from repairing.

Consultants from RCSI College of Drugs and Well being Sciences in Dublin will use tumours and breast most cancers cells donated by sufferers to see within the lab whether or not talazoparib is efficient in treating secondary breast most cancers within the mind.

  • Prof Leonie Younger, one of many co-leads of the analysis workforce, stated: “Our earlier analysis has proven that in lots of circumstances secondary breast most cancers tumours within the mind have modifications in the best way they restore their DNA, and we consider this might make them susceptible to PARP inhibitor medicine like talazoparib.”

Home passes invoice to boost US debt ceiling by way of early December

Nancy Pelosi, the House speaker, on the way to the chamber on Tuesday
Nancy Pelosi, the Home speaker, on the best way to the chamber on Tuesday. Joe Biden is anticipated to signal the measure into legislation this week. {Photograph}: Mandel Ngan/AFP/Getty Photos

The US Home of Representatives gave closing approval on Tuesday to a Senate-passed invoice briefly elevating the federal government’s borrowing restrict to $28.9tn, laying aside the danger of default no less than till early December.

Democrats, who narrowly management the Home, maintained occasion self-discipline to go the hard-fought $480bn debt restrict improve. The vote was alongside occasion traces, with each sure from Democrats and each no from Republicans.

Joe Biden is anticipated to signal the measure into legislation earlier than subsequent Monday, when the treasury division has estimated it will now not be capable of pay the nation’s money owed with out congressional motion.

Republicans insist Democrats ought to take duty for elevating the debt restrict as a result of they wish to spend trillions of {dollars} to increase social packages and deal with local weather change. Democrats say the elevated borrowing authority is required largely to cowl the price of tax cuts and spending packages throughout Donald Trump’s administration, which Home Republicans supported.

  • Home passage warded off issues that the world’s largest financial system would go into default for the primary time, however just for about seven weeks.

  • Lawmakers have till 3 December to go spending laws to stop a authorities shutdown.

William Shatner to blast off on Bezos rocket to turn out to be oldest individual in area

This undated photo made available by Blue Origin in October 2021 shows, from left, Chris Boshuizen, William Shatner, Audrey Powers and Glen de Vries. Their launch scheduled for Wednesday, Oct. 13, 2021 will be Blue Origin’s second passenger flight, using the same capsule and rocket that Jeff Bezos used for his own trup three months earlier. (Blue Origin via AP)
Shatner, second left, together with his New Shepard rocket colleagues Chris Boshuizen, Audrey Powers and Glen de Vries. The rocket will carry off at 8.30am Texas time. {Photograph}: AP

William Shatner, the veteran actor who spent 4 a long time enjoying the fearless commander of Star Trek’s USS Enterprise, was set for a real-life leap into the celebs on Wednesday on the subsequent stage of Jeff Bezos’s quest to dominate the fledgling area tourism trade.

The profitable completion of the 11-minute flight alongside three civilian crew mates, with lift-off of Blue Origin’s New Shepard rocket scheduled for 8.30am CT from its Van Horn, Texas launchpad, would make Shatner, 90, the oldest human to fly into area.

It additionally marks the second tried crewed flight of the rocket system that lifted Bezos, the 57-year-old Amazon founder and world’s richest man, and his brother Mark 66.5 miles into area in July.

Bezos hailed his joyride – which got here 9 days after the British billionaire Sir Richard Branson’s flight to the sting of area onboard Virgin Galactic’s VSS Unity – as “the very best day ever”. The 2 tycoons are sparring with a 3rd rich entrepreneur, Elon Musk of SpaceX.

  • Who else is beaming up with Shatner? The three different passengers are Audrey Powers, a Blue Origin government; Chris Boshuizen, a former Nasa engineer and founding father of the satellite tv for pc Earth imaging firm Planet Labs; and Glen de Vries, the chief government of the medical analysis agency Medidata Options.

In different information …

Diana Morgan Magda, 58, at home in Girard, Ohio
Diana Morgan Magda, 58, at dwelling in Girard, Ohio, the place the fuel was shut off in Might. {Photograph}: Justin Merriman/The Guardian

Stat of the day: Squid Recreation is Netflix’s greatest debut hit, reaching 111m viewers worldwide

Squid Game
Squid Recreation blends a good plot, social allegory and uncompromising violence to create the newest South Korean cultural phenomenon to go world. {Photograph}: Youngkyu Park/Netflix/AFP/Getty Photos

The dystopian South Korean drama Squid Recreation has turn out to be Netflix’s hottest sequence ever, drawing 111 million viewers since its debut lower than 4 weeks in the past, the streaming service stated Tuesday. The unprecedented world viral hit imagines a macabre world by which marginalised persons are pitted towards each other in conventional youngsters’s video games. Whereas the victor can earn hundreds of thousands in money, shedding gamers are killed. Spreading around the globe by phrase of mouth, particularly by way of social media, Squid Recreation has topped Netflix charts in additional than 80 international locations.

Don’t miss this: why white folks get wealthier after disasters however others undergo – an illustrated story

People who are already comfortably well-off are more likely to get assistance after a natural disaster.
People who find themselves already comfortably well-off usually tend to get help after a pure catastrophe. Illustration: Wang Xulin/The Guardian

People who find themselves already comfortably well-off usually tend to get help after a pure catastrophe, which implies the federal government packages find yourself reinforcing inequality. Within the aftermath of Hurricane Harvey in 2017, one household, the Johnsons, acquired cash from their employers in addition to tax breaks from the Federal Emergency Administration Company. They have been capable of transfer to a nicer neighbourhood with flood defence infrastructure. In the meantime Lees, a single mom whose workplace was destroyed, turned homeless.

Local weather verify: carbon emissions ‘will drop simply 40% by 2050 with international locations’ present pledges’

FILE PHOTO: Steam rises at sunrise from the Lethabo Power Station, a coal-fired power station owned by state power utility ESKOM near Sasolburg, South Africa, March 2, 2016. REUTERS/Siphiwe Sibeko/File Photo
Sections of the report present coal use rising strongly, contributing to the second-largest improve in CO2 emissions in historical past. {Photograph}: Siphiwe Sibeko/Reuters

Present plans to chop world carbon emissions will fall 60% in need of the 2050 internet zero goal, the Worldwide Power Company has stated, because it urged leaders to make use of the upcoming Cop26 local weather convention to ship an “unmistakable sign” with concrete coverage plans. In its annual World Power Outlook, redesigned this yr as a “guidebook” for world leaders attending the summit in Glasgow, the IEA predicted that carbon emissions would lower by simply 40% by the center of the century if international locations follow their local weather pledges.

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Final thing: how more and more elaborate ornamental baking turned an internet obsession

Decorated cakes
‘It’s mesmerising to observe the labour folks dedicate to one thing whose sole objective is destruction’. Composite: Instagram/@hamishblakeshotz/@amauryguichon/Tuba Geçkil

In July final yr a video confirmed knives slicing right into a Crocs shoe, a pot plant and a roll of bathroom paper – all revealing spongy innards layered with icing. “These are all desserts,” stated the caption on the video, which has been seen greater than 33m instances on Twitter. They have been the creations of Pink Rose Cake’s Tuba Geçkil, a visible artist turned self-described high fashion cakemaker. As absolutely because it was an indication that individuals had misplaced their minds in lockdown, the transient is-this-cake obsession stemmed, maybe, from the uneasiness these culinary illusions evoke: they mess with our tenuous building of actuality.


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